Cholesterol-directed nanoparticle assemblies based on single amino acid peptide mutations activate cellular uptake and decrease tumor volume.
Cholesterol-directed nanoparticle assemblies based on single amino acid peptide mutations activate cellular uptake and decrease tumor volume. Chem Sci. 2017 Nov 01;8(11):7552-7559 Authors: Li S, Zou R, Tu Y, Wu J, Landry MP Abstract Peptide drugs have been difficult to translate into effective therapies due to their low in vivo stability. Here, we report a […]
Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer’s Disease. Neuroimage Clin. 2018;17:452-464 Authors: Iaccarino L, Tammewar G, Ayakta N, Baker SL, Bejanin A, Boxer AL, Gorno-Tempini ML, Janabi M, Kramer JH, Lazaris A, Lockhart SN, Miller BL, Miller ZA, O’Neil JP, Ossenkoppele R, Rosen HJ, Schonhaut DR, Jagust WJ, Rabinovici GD Abstract […]
Fluorogenic Targeting of Voltage-Sensitive Dyes to Neurons. J Am Chem Soc. 2017 Nov 20;: Authors: Liu P, Grenier V, Hong W, Muller VR, Miller EW Abstract We present a method to target voltage-sensitive fluorescent dyes to specified cells using an enzyme-catalyzed fluorogenic reaction on cell surfaces. The dye/enzyme hybrids are composed of a photoinduced electron […]
Chronic subcutaneous infusion of neurosecretory protein GM increases body mass gain in chicks. Gen Comp Endocrinol. 2017 Nov 16;: Authors: Shikano K, Taniuchi S, Iwakoshi-Ukena E, Furumitsu M, Bentley GE, Kriegsfeld LJ, Ukena K Abstract Recently we discovered a small hypothalamic protein in the chicken, named neurosecretory protein GL (NPGL), which is associated with body […]
Head to head comparison of [(18)F] AV-1451 and [(18)F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia.
Head to head comparison of [(18)F] AV-1451 and [(18)F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia. Eur J Nucl Med Mol Imaging. 2017 Nov 16;: Authors: Jang YK, Lyoo CH, Park S, Oh SJ, Cho H, Oh M, Ryu YH, Choi JY, Rabinovici GD, Kim HJ, Moon SH, Jang H, Lee JS, […]
In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection.
Related Articles In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection. Proc Natl Acad Sci U S A. 2017 Nov 14;: Authors: Aron AT, Heffern MC, Lonergan ZR, Vander Wal MN, Blank BR, Spangler B, Zhang Y, Park HM, Stahl A, Renslo AR, Skaar EP, Chang CJ Abstract […]
Widespread Translational Remodeling during Human Neuronal Differentiation. Cell Rep. 2017 Nov 14;21(7):2005-2016 Authors: Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN Abstract Faithful cellular differentiation requires temporally precise activation of gene expression programs, which are coordinated at the transcriptional and translational levels. Neurons express the most complex set of mRNAs of any human […]
Related Articles Molecular basis for multimerization in the activation of the epidermal growth factor receptor. Elife. 2016 Mar 28;5: Authors: Huang Y, Bharill S, Karandur D, Peterson SM, Marita M, Shi X, Kaliszewski MJ, Smith AW, Isacoff EY, Kuriyan J Abstract The epidermal growth factor receptor (EGFR) is activated by dimerization, but activation also generates […]
Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas.
Related Articles Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas. Cell Rep. 2016 Sep 27;17(1):165-178 Authors: Yao K, Qiu S, Tian L, Snider WD, Flannery JG, Schaffer DV, Chen B Abstract In cold-blooded vertebrates such as zebrafish, Müller glial cells (MGs) readily proliferate to […]