A Ribosomal Perspective on Proteostasis and Aging.
Cell Metab. 2016 Jun 14;23(6):1004-1012
Authors: Steffen KK, Dillin A
As the first and most direct process influencing the proteostasis capacity of a cell, regulation of translation influences lifespan across taxa. Here we highlight some of the newly discovered means by which translational regulation affects cellular proteostasis, with a focus on mechanisms that may ultimately impinge upon the aging process.
PMID: 27304502 [PubMed – indexed for MEDLINE]