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Copper Signaling in the Brain and Beyond.

J Biol Chem. 2017 Oct 30;:

Authors: Ackerman CM, Chang CJ

Abstract
Transition metals have been recognized and studied primarily in the context of their essential roles as structural and metabolic cofactors for biomolecules that compose living systems. More recently, an emerging paradigm of transition metal signaling, where dynamic changes in transition metal pools can modulate protein function, cell fate, and organism health and disease, has broadened our view of the potential contributions of these essential nutrients in biology. Using copper as a canonical example of transition metal signaling, we highlight key experiments where direct measurement and/or visualization of dynamic copper pools, in combination with biochemical, physiological, and behavioral studies, have deciphered sources, targets, and physiological effects of copper signals.

PMID: 29084848 [PubMed – as supplied by publisher]