Related Articles Synapses in the spotlight with synthetic optogenetics. EMBO Rep. 2017 Apr 10;: Authors: Berlin S, Isacoff EY Abstract Membrane receptors and ion channels respond to various stimuli and relay that information across the plasma membrane by triggering specific and timed processes. These include activation of second messengers, allowing ion permeation, and changing cellular excitability, […]
Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors.
Related Articles Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors. Proc Natl Acad Sci U S A. 2017 Apr 10;: Authors: Levitz J, Broichhagen J, Leippe P, Konrad D, Trauner D, Isacoff EY Abstract G protein-coupled receptor (GPCR) signaling occurs in complex spatiotemporal patterns that are difficult to […]
Related Articles The Cerebellum: Adaptive Prediction for Movement and Cognition. Trends Cogn Sci. 2017 Apr 03;: Authors: Sokolov AA, Miall RC, Ivry RB Abstract Over the past 30 years, cumulative evidence has indicated that cerebellar function extends beyond sensorimotor control. This view has emerged from studies of neuroanatomy, neuroimaging, neuropsychology, and brain stimulation, with the […]
Sleep and Human Aging. Neuron. 2017 Apr 05;94(1):19-36 Authors: Mander BA, Winer JR, Walker MP Abstract Older adults do not sleep as well as younger adults. Why? What alterations in sleep quantity and quality occur as we age, and are there functional consequences? What are the underlying neural mechanisms that explain age-related sleep disruption? This […]
First in vivo traumatic brain injury imaging via magnetic particle imaging. Phys Med Biol. 2017 Apr 05;62(9):3501-3509 Authors: Orendorff R, Peck AJ, Zheng B, Shirazi SN, Matthew Ferguson R, Khandhar AP, Kemp SJ, Goodwill P, Krishnan KM, Brooks GA, Kaufer D, Conolly S Abstract Emergency room visits due to traumatic brain injury (TBI) is common, […]
Related Articles Neural and neuroendocrine processing of a non-photic cue in an opportunistically breeding songbird. J Exp Biol. 2016 Mar;219(Pt 6):783-9 Authors: Ernst DK, Bentley GE Abstract Recent studies of the onset of breeding in long-day photoperiodic breeders have focused on the roles of type 2 and 3 iodothyronine deiodinases (DIO2 and DIO3) in the […]
Toward a Rational and Mechanistic Account of Mental Effort. Annu Rev Neurosci. 2017 Mar 31;: Authors: Shenhav A, Musslick S, Lieder F, Kool W, Griffiths TL, Cohen JD, Botvinick MM Abstract In spite of its familiar phenomenology, the mechanistic basis for mental effort remains poorly understood. Although most researchers agree that mental effort is aversive […]
A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore.
Related Articles A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore. J Gen Physiol. 2017 Mar 30;: Authors: Tomczak AP, Fernández-Trillo J, Bharill S, Papp F, Panyi G, Stühmer W, Isacoff EY, Pardo LA Abstract Voltage-gated ion channels couple transmembrane potential changes to ion flow. Conformational changes in […]
GABAA receptor-expressing neurons promote consumption in Drosophila melanogaster. PLoS One. 2017;12(3):e0175177 Authors: Cheung SK, Scott K Abstract Feeding decisions are highly plastic and bidirectionally regulated by neurons that either promote or inhibit feeding. In Drosophila melanogaster, recent studies have identified four GABAergic interneurons that act as critical brakes to prevent incessant feeding. These GABAergic neurons […]