Related Articles Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing. Adv Exp Med Biol. 2017;1016:29-42 Authors: Epstein BE, Schaffer DV Abstract With the recent advent of several generations of targeted DNA nucleases, most recently CRISPR/Cas9, genome editing has become broadly accessible across the biomedical community. Importantly, the capacity of these nucleases to […]
Related Articles Slow-Wave Activity Enhancement to Improve Cognition. Trends Neurosci. 2018 Apr 05;: Authors: Wilckens KA, Ferrarelli F, Walker MP, Buysse DJ Abstract Slow-wave activity (SWA), and its coupling with other sleep features, reorganizes cortical circuitry, supporting cognition. This raises the question: can cognition be improved through SWA enhancement? SWA enhancement techniques range from behavioral […]
hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model.
Related Articles hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model. Stem Cell Reports. 2018 Apr 03;: Authors: Adil MM, Gaj T, Rao AT, Kulkarni RU, Fuentes CM, Ramadoss GN, Ekman FK, Miller EW, Schaffer DV Abstract Huntington disease (HD) is an inherited, progressive neurological disorder characterized […]
Gonadotropin-Inhibitory Hormone (GnIH) and Its Mammalian Ortholog RFamide-Related Peptide-3 (RFRP-3): Discovery and Functional Implications for Reproduction and Stress.
Gonadotropin-Inhibitory Hormone (GnIH) and Its Mammalian Ortholog RFamide-Related Peptide-3 (RFRP-3): Discovery and Functional Implications for Reproduction and Stress. J Neuroendocrinol. 2018 Apr 06;:e12597 Authors: Kriegsfeld LJ, Jennings KJ, Bentley GE, Tsutsui K Abstract At the turn of the millennium, a neuropeptide with pronounced inhibitory actions on avian pituitary gonadotropin secretion was identified and named gonadotropin-inhibitory […]
Germanium as a scalable sacrificial layer for nanoscale protein patterning. PLoS One. 2018;13(4):e0195062 Authors: Lu B, Maharbiz MM Abstract We demonstrate the use of germanium (Ge) films as water-soluble features that allow the patterning of proteins onto surfaces with commonly used organic solvents. This technique is scalable for manufacturing and is compatible with nano- and […]
Subjective Value Representations during Effort, Probability, and Time Discounting across Adulthood. Soc Cogn Affect Neurosci. 2018 Mar 28;: Authors: Seaman KL, Brooks N, Karrer TM, Castrellon JJ, Perkins SF, Dang L, Hsu M, Zald DH, Samanez-Larkin GR Abstract Every day, humans make countless decisions which require the integration of information about potential benefits (i.e., rewards) […]
Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits.
Engineered viral vectors for functional interrogation, deconvolution, and manipulation of neural circuits. Curr Opin Neurobiol. 2018 Mar 31;50:163-170 Authors: Sun S, Schaffer DV Abstract Optimization of traditional replication-competent viral tracers has granted access to immediate synaptic partners of target neuronal populations, enabling the dissection of complex brain circuits into functional neural pathways. The excessive virulence […]
In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease.
Related Articles In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2016 12 13;113(50):14219-14224 Authors: Heffern MC, Park HM, Au-Yeung HY, Van de Bittner GC, Ackerman CM, Stahl A, Chang CJ Abstract Copper is a required metal nutrient for life, but […]
Related Articles The Sense of Smell Impacts Metabolic Health and Obesity. Cell Metab. 2017 Jul 05;26(1):198-211.e5 Authors: Riera CE, Tsaousidou E, Halloran J, Follett P, Hahn O, Pereira MMA, Ruud LE, Alber J, Tharp K, Anderson CM, Brönneke H, Hampel B, Filho CDM, Stahl A, Brüning JC, Dillin A Abstract Olfactory inputs help coordinate food […]