Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor. Nat Commun. 2017 Nov 30;8(1):1862 Authors: Berry MH, Holt A, Levitz J, Broichhagen J, Gaub BM, Visel M, Stanley C, Aghi K, Kim YJ, Trauner D, Flannery J, Isacoff EY Abstract Retinitis pigmentosa results in blindness due to degeneration of photoreceptors, but spares other […]
Optogenetic Retinal Gene Therapy with the Light Gated GPCR Vertebrate Rhodopsin. Methods Mol Biol. 2018;1715:177-189 Authors: Gaub BM, Berry MH, Visel M, Holt A, Isacoff EY, Flannery JG Abstract In retinal disease, despite the loss of light sensitivity as photoreceptors die, many retinal interneurons survive in a physiologically and metabolically functional state for long periods. […]
Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas.
Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas. Methods Mol Biol. 2018;1715:239-249 Authors: Day TP, Byrne LC, Flannery JG, Schaffer DV Abstract Adeno-associated virus (AAV) has shown promise as a therapeutic gene delivery vector for inherited retinal degenerations in both preclinical disease models and human clinical trials. The retinas […]
Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions.
Related Articles Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 05;372(1715): Authors: Keck T, Toyoizumi T, Chen L, Doiron B, Feldman DE, Fox K, Gerstner W, Haydon PG, Hübener M, Lee HK, Lisman JE, Rose T, Sengpiel F, […]
Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.
Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia. JAMA Psychiatry. 2017 Nov 29;: Authors: Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleó A, Mintun MA, Wallin A, Engelborghs S, Na DL, Chételat G, Molinuevo JL, Landau […]
NuMA recruits dynein activity to microtubule minus-ends at mitosis. Elife. 2017 Nov 29;6: Authors: Hueschen CL, Kenny SJ, Xu K, Dumont S Abstract To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized activity at ends is predicted to […]
Related Articles Multiple shared mechanisms for homeostatic plasticity in rodent somatosensory and visual cortex. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 05;372(1715): Authors: Gainey MA, Feldman DE Abstract We compare the circuit and cellular mechanisms for homeostatic plasticity that have been discovered in rodent somatosensory (S1) and visual (V1) cortex. Both areas […]
Related Articles A potential role for glia-derived extracellular matrix remodeling in postinjury epilepsy. J Neurosci Res. 2016 Sep;94(9):794-803 Authors: Kim SY, Porter BE, Friedman A, Kaufer D Abstract Head trauma and vascular injuries are known risk factors for acquired epilepsy. The sequence of events that lead from the initial injury to the development of epilepsy […]
MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans.
Related Articles MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans. G3 (Bethesda). 2016 Apr 07;6(4):1121-30 Authors: Chen Y, Bharill S, O’Hagan R, Isacoff EY, Chalfie M Abstract The Caenorhabditis elegans DEG/ENaC proteins MEC-4 and MEC-10 transduce gentle touch in the six touch receptor neurons . Gain-of-function mutations of mec-4 […]