Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor. Nat Commun. 2017 Nov 30;8(1):1862 Authors: Berry MH, Holt A, Levitz J, Broichhagen J, Gaub BM, Visel M, Stanley C, Aghi K, Kim YJ, Trauner D, Flannery J, Isacoff EY Abstract Retinitis pigmentosa results in blindness due to degeneration of photoreceptors, but spares other […]
Related Articles Spatial resolution dependence on spectral frequency in human speech cortex electrocorticography. J Neural Eng. 2016 Oct;13(5):056013 Authors: Muller L, Hamilton LS, Edwards E, Bouchard KE, Chang EF Abstract OBJECTIVE: Electrocorticography (ECoG) has become an important tool in human neuroscience and has tremendous potential for emerging applications in neural interface technology. Electrode array design […]
Entorhinal tau pathology, episodic memory decline and neurodegeneration in aging. J Neurosci. 2017 Nov 30;: Authors: Maass A, Lockhart SN, Harrison TM, Bell RK, Mellinger T, Swinnerton K, Baker SL, Rabinovici GD, Jagust WJ Abstract The medial temporal lobe (MTL) is an early site of tau accumulation and MTL dysfunction may underlie episodic memory decline […]
Related Articles Imaging the visual system: from the eye to the brain. Ophthalmic Physiol Opt. 2016 05;36(3):213-7 Authors: Thompson B, Read SA, Dumoulin SO, Elsner AE, Porter J, Roorda A PMID: 27112221 [PubMed – indexed for MEDLINE]
Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas.
Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas. Methods Mol Biol. 2018;1715:239-249 Authors: Day TP, Byrne LC, Flannery JG, Schaffer DV Abstract Adeno-associated virus (AAV) has shown promise as a therapeutic gene delivery vector for inherited retinal degenerations in both preclinical disease models and human clinical trials. The retinas […]
Related Articles A potential role for glia-derived extracellular matrix remodeling in postinjury epilepsy. J Neurosci Res. 2016 Sep;94(9):794-803 Authors: Kim SY, Porter BE, Friedman A, Kaufer D Abstract Head trauma and vascular injuries are known risk factors for acquired epilepsy. The sequence of events that lead from the initial injury to the development of epilepsy […]
Related Articles Multiple shared mechanisms for homeostatic plasticity in rodent somatosensory and visual cortex. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 05;372(1715): Authors: Gainey MA, Feldman DE Abstract We compare the circuit and cellular mechanisms for homeostatic plasticity that have been discovered in rodent somatosensory (S1) and visual (V1) cortex. Both areas […]
NuMA recruits dynein activity to microtubule minus-ends at mitosis. Elife. 2017 Nov 29;6: Authors: Hueschen CL, Kenny SJ, Xu K, Dumont S Abstract To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized activity at ends is predicted to […]
Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions.
Related Articles Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 05;372(1715): Authors: Keck T, Toyoizumi T, Chen L, Doiron B, Feldman DE, Fox K, Gerstner W, Haydon PG, Hübener M, Lee HK, Lisman JE, Rose T, Sengpiel F, […]