Recent publications

Below are recent publications by Berkeley Neuroscience faculty. Click here to view all faculty publications on PubMed.

Performance Assessment and Selection of Normalization Procedures for Single-Cell RNA-Seq.

Performance Assessment and Selection of Normalization Procedures for Single-Cell RNA-Seq. Cell Syst. 2019 Apr 24;8(4):315-328.e8 Authors: Cole MB, Risso D, Wagner A, DeTomaso D, Ngai J, Purdom E, Dudoit S, Yosef N Abstract Systematic measurement biases make normalization an essential step in single-cell RNA sequencing (scRNA-seq) analysis. There may be multiple competing considerations behind the assessment […]

Gustatory Processing in Drosophila melanogaster.

Related Articles Gustatory Processing in Drosophila melanogaster. Annu Rev Entomol. 2018 01 07;63:15-30 Authors: Scott K Abstract The ability to identify nutrient-rich food and avoid toxic substances is essential for an animal’s survival. Although olfaction and vision contribute to food detection, the gustatory system acts as a final checkpoint control for food acceptance or rejection. […]

Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation.

Bioinspired Thiophosphorodichloridate Reagents for Chemoselective Histidine Bioconjugation. J Am Chem Soc. 2019 Apr 24;: Authors: Jia S, He D, Chang CJ Abstract Site-selective bioconjugation to native protein residues is a powerful tool for protein functionalization, with cysteine and lysine side chains being the most common points for attachment owing to their high nucleophilicity. We now […]

The Lysosome, Elixir of Neural Stem Cell Youth.

Related Articles The Lysosome, Elixir of Neural Stem Cell Youth. Cell Stem Cell. 2018 05 03;22(5):619-620 Authors: Simic MS, Dillin A Abstract Recently in Science, Leeman et al. find that perturbing lysosomal activity of quiescent NSCs directly impedes their ability to become activated, similar to what happens during aging. Excitingly, they could rejuvenate old quiescent NSCs […]

Cheaper and less variable expansion.

Related Articles Cheaper and less variable expansion. Nat Biomed Eng. 2018 Mar;2(3):144-145 Authors: Adil MM, Schaffer DV PMID: 31015716 [PubMed – in process]

Probing demyelination and remyelination of the cuprizone mouse model using multimodality MRI.

Related Articles Probing demyelination and remyelination of the cuprizone mouse model using multimodality MRI. J Magn Reson Imaging. 2019 Apr 22;: Authors: Wang N, Zhuang J, Wei H, Dibb R, Qi Y, Liu C Abstract BACKGROUND: Various studies by MRI exhibit that the corpus callosum (CC) is the most vulnerable to cuprizone administration, detecting the […]

Matrix degradation: Making way for neural stemness.

Related Articles Matrix degradation: Making way for neural stemness. Nat Mater. 2017 11 24;16(12):1174-1176 Authors: Kang PH, Kumar S, Schaffer DV PMID: 29170553 [PubMed – indexed for MEDLINE]

Double dissociation of single-interval and rhythmic temporal prediction in cerebellar degeneration and Parkinson’s disease.

Related Articles Double dissociation of single-interval and rhythmic temporal prediction in cerebellar degeneration and Parkinson’s disease. Proc Natl Acad Sci U S A. 2018 11 27;115(48):12283-12288 Authors: Breska A, Ivry RB Abstract Predicting the timing of upcoming events is critical for successful interaction in a dynamic world, and is recognized as a key computation for […]

CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window.

Related Articles CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window. Nature. 2018 08;560(7717):248-252 Authors: Halperin SO, Tou CJ, Wong EB, Modavi C, Schaffer DV, Dueber JE Abstract The capacity to diversify genetic codes advances our ability to understand and engineer biological systems1,2. A method for continuously diversifying user-defined regions of a […]