Widespread Translational Remodeling during Human Neuronal Differentiation. Cell Rep. 2017 Nov 14;21(7):2005-2016 Authors: Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN Abstract Faithful cellular differentiation requires temporally precise activation of gene expression programs, which are coordinated at the transcriptional and translational levels. Neurons express the most complex set of mRNAs of any human […]
Related Articles Molecular basis for multimerization in the activation of the epidermal growth factor receptor. Elife. 2016 Mar 28;5: Authors: Huang Y, Bharill S, Karandur D, Peterson SM, Marita M, Shi X, Kaliszewski MJ, Smith AW, Isacoff EY, Kuriyan J Abstract The epidermal growth factor receptor (EGFR) is activated by dimerization, but activation also generates […]
Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas.
Related Articles Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas. Cell Rep. 2016 Sep 27;17(1):165-178 Authors: Yao K, Qiu S, Tian L, Snider WD, Flannery JG, Schaffer DV, Chen B Abstract In cold-blooded vertebrates such as zebrafish, Müller glial cells (MGs) readily proliferate to […]
Related Articles Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing. Adv Exp Med Biol. 2017;1016:29-42 Authors: Epstein BE, Schaffer DV Abstract With the recent advent of several generations of targeted DNA nucleases, most recently CRISPR/Cas9, genome editing has become broadly accessible across the biomedical community. Importantly, the capacity of these nucleases to […]
Related Articles Fluid reasoning predicts future mathematical performance among children and adolescents. J Exp Child Psychol. 2017 May;157:125-143 Authors: Green CT, Bunge SA, Briones Chiongbian V, Barrow M, Ferrer E Abstract The aim of this longitudinal study was to determine whether fluid reasoning (FR) plays a significant role in the acquisition of mathematics skills above […]
Related Articles Seizure Suppression by High Temperature via cAMP Modulation in Drosophila. G3 (Bethesda). 2016 Oct 13;6(10):3381-3387 Authors: Saras A, Tanouye MA Abstract Bang-sensitive (BS) Drosophila mutants display characteristic seizure-like activity (SLA) and paralysis after mechanical shock . After high-frequency electrical stimulation (HFS) of the brain, they generate robust seizures at very low threshold voltage. […]
Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration.
Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration. Exp Eye Res. 2017 Nov 06;: Authors: LaVail MM, Nishikawa S, Steinberg RH, Naash MI, Duncan JL, Trautmann N, Matthes MT, Yasumura D, Lau-Villacorta C, Chen J, Peterson WM, Yang H, Flannery JG Abstract We produced 8 lines of transgenic (Tg) […]
Considerations and code for partial volume correcting [(18)F]-AV-1451 tau PET data. Data Brief. 2017 Dec;15:648-657 Authors: Baker SL, Maass A, Jagust WJ Abstract [(18)F]-AV-1451 is a leading tracer used with positron emission tomography (PET) to quantify tau pathology. However, [(18)F]-AV-1451 shows “off target” or non-specific binding, which we define as binding of the tracer in […]
Influence of hippocampal niche signals on neural stem cell functions during aging. Cell Tissue Res. 2017 Nov 10;: Authors: Mosher KI, Schaffer DV Abstract The genesis of new neurons from neural stem cells in the adult brain offers the hope that this mechanism of plasticity can be harnessed for the treatment of brain injuries and […]