Adolescence and “Late Blooming” Synapses of the Prefrontal Cortex. Cold Spring Harb Symp Quant Biol. 2019 Jan 23;: Authors: Delevich K, Thomas AW, Wilbrecht L Abstract The maturation of the prefrontal cortex (PFC) during adolescence is thought to be important for cognitive and affective development and mental health risk. Whereas many summaries of adolescent development […]
Related Articles Serial dependence in position occurs at the time of perception. Psychon Bull Rev. 2018 Dec;25(6):2245-2253 Authors: Manassi M, Liberman A, Kosovicheva A, Zhang K, Whitney D Abstract Observers perceive objects in the world as stable over space and time, even though the visual experience of those objects is often discontinuous and distorted due […]
Related Articles Spectral Imprints of Working Memory for Everyday Associations in the Frontoparietal Network. Front Syst Neurosci. 2018;12:65 Authors: Johnson EL, King-Stephens D, Weber PB, Laxer KD, Lin JJ, Knight RT Abstract How does the human brain rapidly process incoming information in working memory? In growing divergence from a single-region focus on the prefrontal cortex […]
Related Articles Causal contribution and dynamical encoding in the striatum during evidence accumulation. Elife. 2018 08 24;7: Authors: Yartsev MM, Hanks TD, Yoon AM, Brody CD Abstract A broad range of decision-making processes involve gradual accumulation of evidence over time, but the neural circuits responsible for this computation are not yet established. Recent data indicate […]
Acute silencing of hippocampal CA3 reveals a dominant role in place field responses. Nat Neurosci. 2019 Jan 21;: Authors: Davoudi H, Foster DJ Abstract Neurons in hippocampal output area CA1 are thought to exhibit redundancy across cortical and hippocampal inputs. Here we show instead that acute silencing of CA3 terminals drastically reduces place field responses […]
Related Articles Superficial layers suppress the deep layers to fine tune cortical coding. J Neurosci. 2019 Jan 16;: Authors: Pluta SR, Telian GI, Naka A, Adesnik H Abstract The descending microcircuit from layer 2/3 (L2/3) to layer 5 (L5) is one of the strongest excitatory pathways in the cortex, presumably forming a core component of […]
A TREK to Translate Genetics to Mechanisms of Migraine. Neuron. 2019 Jan 16;101(2):193-195 Authors: Hill RZ, Bautista DM Abstract In this issue of Neuron, Royal et al. (2018) find that a mutant form of the TRESK ion channel linked to migraine undergoes alternative translation to produce an inhibitory protein that blocks TREK channels, leading to neuronal […]
In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ.
Related Articles In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ. Mol Ther. 2018 01 03;26(1):304-319 Authors: Ojala DS, Sun S, Santiago-Ortiz JL, Shapiro MG, Romero PA, Schaffer DV Abstract Directed evolution continues to expand the capabilities of complex biomolecules for […]
Design of a Highly Bistable Photoswitchable Tethered Ligand for Rapid and Sustained Manipulation of Neurotransmission.
Related Articles Design of a Highly Bistable Photoswitchable Tethered Ligand for Rapid and Sustained Manipulation of Neurotransmission. J Am Chem Soc. 2018 06 20;140(24):7445-7448 Authors: Lin WC, Tsai MC, Rajappa R, Kramer RH Abstract Photoswitchable neurotransmitter receptors are powerful tools for precise manipulation of neural signaling. However, their applications for slow or long-lasting biological events […]