Proliferation versus Differentiation: Redefining Retinoic Acid’s Role.
Stem Cell Reports. 2018 Jun 05;10(6):1673-1675
Authors: Mosher KI, Schaffer DV
Retinoic acid is commonly used in culture to differentiate stem cells into neurons and has established neural differentiation functions in vivo in developing and adult organisms. In this issue of Stem Cell Reports, Mishra et al. (2018) broaden its role in stem cell functions, showing that retinoic acid is necessary for stem and progenitor cell proliferation in the adult brain.
PMID: 29874625 [PubMed – in process]