The Lysosome, Elixir of Neural Stem Cell Youth.
Cell Stem Cell. 2018 05 03;22(5):619-620
Authors: Simic MS, Dillin A
Recently in Science, Leeman et al. find that perturbing lysosomal activity of quiescent NSCs directly impedes their ability to become activated, similar to what happens during aging. Excitingly, they could rejuvenate old quiescent NSCs by enhancing the lysosome pathway, ameliorating their ability to clear protein aggregates and become activated.
PMID: 29727677 [PubMed – indexed for MEDLINE]