Related Articles CRISPR-guided DNA polymerases enable diversification of all nucleotides in a tunable window. Nature. 2018 08;560(7717):248-252 Authors: Halperin SO, Tou CJ, Wong EB, Modavi C, Schaffer DV, Dueber JE Abstract The capacity to diversify genetic codes advances our ability to understand and engineer biological systems1,2. A method for continuously diversifying user-defined regions of a […]
For many people today, amyotrophic lateral sclerosis, aka ALS or Lou Gehrig’s disease, is most commonly linked with both the fundraising Ice Bucket Challenge and one its most famous patients, the physicist Stephen Hawking. However, it could soon have a brand-new distinction — the next disease to be treatable using CRISPR-Cas9 gene-editing technology. In work carried out by researchers at University […]
University of California, Berkeley scientists have for the first time used CRISPR-Cas9 gene editing to disable a defective gene that causes amyotrophic lateral sclerosis, or Lou Gehrig’s disease, in mice, extending their lifespan by 25 percent. The therapy delayed the onset of the muscle wasting that characterizes the disease, which results in progressive weakness and […]
In two new papers, the Dan lab reveals new neurons, circuits, and brain areas that regulate sleep, opening the door to a better understanding of this critical state.
Intercellular communication is required for trap formation in the nematode-trapping fungus Duddingtonia flagrans.
Intercellular communication is required for trap formation in the nematode-trapping fungus Duddingtonia flagrans. PLoS Genet. 2019 Mar 27;15(3):e1008029 Authors: Youssar L, Wernet V, Hensel N, Yu X, Hildebrand HG, Schreckenberger B, Kriegler M, Hetzer B, Frankino P, Dillin A, Fischer R Abstract Nematode-trapping fungi (NTF) are a large and diverse group of fungi, which may […]
Modeling a neurodevelopmental disorder with human brain organoids: a new way to study conditions such as epilepsy and autism
When brain development goes awry, the consequences can be devastating. The developmental disorder tuberous sclerosis complex (TSC) causes the formation of cortical tubers—disorganized regions of abnormal cells in the cerebral cortex of the brain—and often results in epilepsy, autism spectrum disorder, intellectual disability, and psychiatric disorders. Berkeley Neuroscience faculty member Helen Bateup wants to understand […]
Annual Message from Ehud Isacoff Director, Berkeley Neuroscience and Berkeley Brain Initiative (2013-present) Professor of Neurobiology, Molecular and Cell Biology Department –December 5, 2018– Berkeley Neuroscience spans twelve departments, and at its core, our faculty and their research groups apply their diverse expertise and approaches to add to our knowledge about the brain in health, illness, and […]
UC Berkeley neuroscience and engineering professor Michael Yartsev has been awarded a 2017 Packard Fellowship for Science and Engineering. The fellowships, given by the David and Lucile Packard Foundation, go to 18 of the nation’s most innovative, early-career scientists and engineers. Yartsev will receive $875,000 over five years to pursue new research into how our brains […]