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Versatile multi-detector scheme for adaptive optics scanning laser ophthalmoscopy.

Biomed Opt Express. 2018 Nov 01;9(11):5477-5488

Authors: Mozaffari S, Jaedicke V, LaRocca F, Tiruveedhula P, Roorda A

Abstract
Adaptive optics scanning laser ophthalmoscopy (AOSLO) is a powerful tool for imaging the retina at high spatial and temporal resolution. In this paper, we present a multi-detector scheme for AOSLO which has two main configurations: pixel reassignment and offset aperture imaging. In this detection scheme, the single element detector of the standard AOSLO is replaced by a fiber bundle which couples the detected light into multiple detectors. The pixel reassignment configuration enables high resolution imaging with an increased light collection. The increase in signal-to-noise ratio (SNR) from this configuration can improve the accuracy of motion registration techniques. The offset aperture imaging configuration enhances the detection of multiply scattered light, which improves the contrast of retinal vasculature and inner retinal layers similar to methods such as nonconfocal split-detector imaging and multi-offset aperture imaging.

PMID: 30460141 [PubMed]