From Kansas to Mission Bay: An interview with Professional in Residence Timothy Day

I explored it for a year and a half or so, kind of dabbled with a couple of classes or meetups or trying to talk to people trying to learn: How does this actually work? Then at the end of that experience I met my co-founder Mubhij Ahmad in graduate school. He had an idea for doing gene therapy in the gastrointestinal tract; my PhD was delivering it to the eye, so we thought, “Okay, let’s figure out how to deliver it to a different tissue.”

During this time, I took advantage of the CITRIS Foundry and Launch, and I did a couple of Haas School business seminars and a couple of Sutardja Dai entrepreneurship program courses.

Then we applied to IndieBio as an accelerator program. I took a leave of absence from my PhD to pursue that for the summer, and I was fortunate to have PIs that were very supportive. We were able to generate data that was compelling enough to get venture capitalists to invest in our company, DNALite. That also timed nicely with me graduating, so I transitioned full-time to doing this company. So that’s the “From Kansas to Mission Bay” story.

LG: Wow! How did you balance all of that alongside your PhD?

TD: Spending a lot of nights and weekends, especially when we were starting the company, because we were not a lab spin out. It was our own idea, so we had to get outside funding, we had to find spaces where we could, as a commercial entity, operate, and we were trying to apply for grants. We were also very naïve, thinking “Oh we’re right next to Silicon Valley and we have this cool idea—let’s just go pitch investors!” We pitched investors with no data, no plan, nothing. I learned that you can approach these people, because we talked to a large number of them. But pretty much all of them told us in nice ways “Look, you guys have to have something more than an idea—everybody has an idea, but you have to make it more practical.”

LG: What does your day-to-day looks like now as the CSO of DNALite?

TD: I’m the on the science side, so my day-to-day is definitely managing the scientific activities and making sure that people have what they need to do the experiments to reach our scientific goals. It’s a lot of planning the experiments with people, reviewing data, analyzing it, helping them… We’re also always talking to different potential partners. You might be talking to a pharmaceutical company, your current investors or future potential investors, or to vendors and suppliers. It’s also talking to scientists and doctors and other people, talking to manufacturers to be able to scale things, talking to our IP [intellectual property] people here. I’m more inward facing, helping the team day-to-day, whereas my co-founder, Mubhij, is more outward facing, so he does more of the initial investor calls and partnership management.

LG: What then would you say is your favorite part of running DNALite and what’s the biggest challenge?

TD: My favorite parts are: One, working with the team. I like working in a team context, where we’re trying to accomplish a goal together and different people are contributing to the overall goal. And two, I like reaching out to new scientists or investors, and then talking about what we’re trying to do and finding other like-minded people. It’s really fun to find people who are interested in your technology or want to work with you together on it.

The biggest challenge? Juggling a lot of different things—there’s a side of it that’s fun, because there’s a lot of stimuli and a lot of variety—but when you’re really slammed, managing that or losing sleep over different speed bumps that you hit is probably my least favorite part. But that’s what makes it interesting; if it wasn’t painful sometimes, the fun times wouldn’t be as good!

LG: How do you communicate with the scientists on your team in an area where you have expertise, as well as talk to investors who may know nothing about what you’re doing?

TD: The best analogy I’ve heard is it’s like Google maps where you zoom in and out of depth. There’re parts of the globe that are grayed out for me, but at a high at a high level, I can talk about everything that is relevant to the company. I have to be able to talk about everything because there are times where we have multiple pitch meetings scheduled at the same time, so I have to be comfortable pitching the business part and IP part as well.

It’s really trying to know your audience and doing your homework. With investors or other scientists, you kind of know angles that you could take if you’re talking to an immunologist or deep biotech investor versus a tech investor who’s going into biotech for the first time.

I think that’s my job—to try to be perceptive enough to try to meet people where they’re at and not fall into the temptation to BS in places that I don’t know. Because if you do that and get called out, you lose all trust, so I think it’s okay to say, “I don’t know or I will find out.”

But then that’s a great thing about having a team. Yeah, I don’t have as much in-depth understanding about mucosal immunology, but we do have a PhD scientist who did that at Harvard for his post-doc—let’s talk to him on the next call!

My job is to try and meet the people where they are and to communicate effectively. The more I can do that the more I make my own life easier, especially for investors. They’re hearing hundreds of pitches, and if you have this complex, nuanced solution, they might just take one piece of that’s not even the right piece…boil it down and have your messaging, and then you can dive into some deep things. Sometimes it’s a good strategy to dive in deep to show “Look, I know this stuff,” and then go back up.

Timothy Day is the co-founder and CSO of DNALite Therapeutics, which is developing gene therapies for oral delivery in the treatment of gastrointestinal tract diseases. After obtaining his bachelor’s degree in Microbiology at the University of Kansas, he completed his PhD in Neuroscience (’17) in the laboratories of John Flannery and  David Schaffer at UC Berkeley, where he worked on gene therapy delivery to the eye. Day has participated in several incubator programs for entrepreneurs including the CITRIS Foundry, Launch, and IndieBio during DNALite’s growth. 

Leah Gulyas is a PhD candidate in Plant and Microbial Biology in Britt Glaunsinger’s lab. Her research aims at understanding the manipulation of host transcriptional machinery during viral infection.

Source: https://qb3.berkeley.edu/news/timothy-day-interview-pir/