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Sex differences in the genetic architecture underlying resilience in AD
Alzheimers Dement. 2021 Dec;17 Suppl 3:e055010. doi: 10.1002/alz.055010.
ABSTRACT
BACKGROUND: Approximately 30% of older adults are cognitively normal at death despite presence of Alzheimer's disease (AD) neuropathology at autopsy. Studying these "resilient" individuals may
...Read more about Sex differences in the genetic architecture underlying resilience in ADLongitudinal Early-onset Alzheimer's Disease Study (LEADS) genetic screening: Initial results
Alzheimers Dement. 2021 Dec;17 Suppl 3:e056493. doi: 10.1002/alz.056493.
ABSTRACT
BACKGROUND: The Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) aims to enroll and study participants with sporadic early-onset Alzheimer's disease (EOAD) or early-onset non-Alzheimer
...Read more about Longitudinal Early-onset Alzheimer's Disease Study (LEADS) genetic screening: Initial resultsLong-Term Motor Learning in the "Wild" With High Volume Video Game Data
Front Hum Neurosci. 2021 Dec 20;15:777779. doi: 10.3389/fnhum.2021.777779. eCollection 2021.
ABSTRACT
Motor learning occurs over long periods of practice during which motor acuity, the ability to execute actions more accurately, precisely, and in less time, improves.
...Read more about Long-Term Motor Learning in the "Wild" With High Volume Video Game DataWhat do Reinforcement Learning Models Measure? Interpreting Model Parameters in Cognition and Neuroscience
Curr Opin Behav Sci. 2021 Oct;41:128-137. doi: 10.1016/j.cobeha.2021.06.004. Epub 2021 Jul 3.
ABSTRACT
Reinforcement learning (RL) is a concept that has been invaluable to fields including machine learning, neuroscience, and cognitive science. However, what RL entails differs
...Read more about What do Reinforcement Learning Models Measure? Interpreting Model Parameters in Cognition and NeuroscienceA silicon-rhodamine chemical-genetic hybrid for far red voltage imaging from defined neurons in brain slice
RSC Chem Biol. 2021 Sep 29;2(6):1594-1599. doi: 10.1039/d1cb00156f. eCollection 2021 Dec 2.
ABSTRACT
We describe the design, synthesis, and application of voltage-sensitive silicon rhodamines. Based on the Berkeley Red Sensor of Transmembrane potential, or BeRST, scaffold,
...Read more about A silicon-rhodamine chemical-genetic hybrid for far red voltage imaging from defined neurons in brain sliceDistinct Factors Drive the Spatiotemporal Progression of Tau Pathology in Older Adults
J Neurosci. 2022 Feb 16;42(7):1352-1361. doi: 10.1523/JNEUROSCI.1601-21.2021. Epub 2021 Dec 29.
ABSTRACT
Mechanisms underlying the initial accumulation of tau pathology across the human brain are largely unknown. We examined whether baseline factors including age, amyloid-β (
...Read more about Distinct Factors Drive the Spatiotemporal Progression of Tau Pathology in Older AdultsCognitive strategies shift information from single neurons to populations in prefrontal cortex
Neuron. 2022 Feb 16;110(4):709-721.e4. doi: 10.1016/j.neuron.2021.11.021. Epub 2021 Dec 20.
ABSTRACT
Neurons in primate lateral prefrontal cortex (LPFC) play a critical role in working memory (WM) and cognitive strategies. Consistent with adaptive coding models, responses of
...Read more about Cognitive strategies shift information from single neurons to populations in prefrontal cortexThe retrocalcarine sulcus maps different retinotopic representations in macaques and humans
Brain Struct Funct. 2022 May;227(4):1227-1245. doi: 10.1007/s00429-021-02427-0. Epub 2021 Dec 17.
ABSTRACT
Primate cerebral cortex is highly convoluted with much of the cortical surface buried in sulcal folds. The origins of cortical folding and its functional relevance have
...Read more about The retrocalcarine sulcus maps different retinotopic representations in macaques and humansRegional gray matter oligodendrocyte- and myelin-related measures are associated with differential susceptibility to stress-induced behavior in rats and humans
Transl Psychiatry. 2021 Dec 13;11(1):631. doi: 10.1038/s41398-021-01745-5.
ABSTRACT
Individual reactions to traumatic stress vary dramatically, yet the biological basis of this variation remains poorly understood. Recent studies demonstrate the surprising plasticity of
...Read more about Regional gray matter oligodendrocyte- and myelin-related measures are associated with differential susceptibility to stress-induced behavior in rats and humansStructural basis for pH gating of the two-pore domain K<sup>+/sup> channel TASK2
Nature. 2020 Sep 30. doi: 10.1038/s41586-020-2770-2. Online ahead of print.
ABSTRACT
TASK2 (also known as KCNK5) channels generate pH-gated leak-type K+ currents to control cellular electrical excitability1-3. TASK2 is involved in the regulation of
...Read more about Structural basis for pH gating of the two-pore domain K+/sup> channel TASK2Magnetotactic bacteria accumulate a large pool of iron distinct from their magnetite crystals
Appl Environ Microbiol. 2020 Sep 4:AEM.01278-20. doi: 10.1128/AEM.01278-20. Online ahead of print.
ABSTRACT
Magnetotactic bacteria (MTB) are ubiquitous aquatic microorganisms that form intracellular nanoparticles of magnetite (Fe3O4) or greigite (Fe
...Read more about Magnetotactic bacteria accumulate a large pool of iron distinct from their magnetite crystalsSleep Disturbance Forecasts β-Amyloid Accumulation across Subsequent Years
Curr Biol. 2020 Aug 28:S0960-9822(20)31171-4. doi: 10.1016/j.cub.2020.08.017. Online ahead of print.
ABSTRACT
Experimental sleep-wake disruption in rodents and humans causally modulates β-amyloid (Aβ) dynamics (e.g., [1-3]). This leads to the hypothesis that, beyond cross-
...Read more about Sleep Disturbance Forecasts β-Amyloid Accumulation across Subsequent YearsBeyond dichotomies in reinforcement learning
Nat Rev Neurosci. 2020 Oct;21(10):576-586. doi: 10.1038/s41583-020-0355-6. Epub 2020 Sep 1.
ABSTRACT
Reinforcement learning (RL) is a framework of particular importance to psychology, neuroscience and machine learning. Interactions between these fields, as promoted through
...Read more about Beyond dichotomies in reinforcement learningCorrigendum to "Disentangling the systems contributing to changes in learning during adolescence" [Dev. Cogn. Neurosci. 41, 2020, 100732]
Dev Cogn Neurosci. 2020 Oct;45:100854. doi: 10.1016/j.dcn.2020.100854. Epub 2020 Aug 28.
NO ABSTRACT
PMID:
...Read more about Corrigendum to "Disentangling the systems contributing to changes in learning during adolescence" [Dev. Cogn. Neurosci. 41, 2020, 100732]Rethinking amblyopia 2020
Vision Res. 2020 Nov;176:118-129. doi: 10.1016/j.visres.2020.07.014. Epub 2020 Aug 28.
ABSTRACT
Recent work has transformed our ideas about the neural mechanisms, behavioral consequences and effective therapies for amblyopia. Since the 1700's, the clinical treatment for
...Read more about Rethinking amblyopia 2020Defect-Accommodating Intermediates Yield Selective Low-Temperature Synthesis of YMnO<sub>3</sub> Polymorphs
Inorg Chem. 2020 Sep 21;59(18):13639-13650. doi: 10.1021/acs.inorgchem.0c02023. Epub 2020 Aug 31.
ABSTRACT
In the synthesis of complex oxides, solid-state metathesis provides low-temperature reactions where product selectivity can be achieved through simple changes in
...Read more about Defect-Accommodating Intermediates Yield Selective Low-Temperature Synthesis of YMnO3 PolymorphsBerkeley Neuroscience members meet prospective PhD students at fall conferences
Drugs that quell brain inflammation reverse dementia
Isacoff receives McKnight Memory and Cognitive Disorders Award
Schaffer and Ivry elected fellows of the AAAS
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